Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects.
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ABSTRACT:
SUBMITTER: Mahu I
PROVIDER: S-EPMC7671941 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects.
Mahú Inês I Barateiro Andreia A Rial-Pensado Eva E Martinéz-Sánchez Noelia N Vaz Sandra H SH Cal Pedro M S D PMSD Jenkins Benjamin B Rodrigues Tiago T Cordeiro Carlos C Costa Miguel F MF Mendes Raquel R Seixas Elsa E Pereira Mafalda M A MMA Kubasova Nadiya N Gres Vitka V Morris Imogen I Temporão Carolina C Olivares Marta M Sanz Yolanda Y Koulman Albert A Corzana Francisco F Sebastião Ana M AM López Miguel M Bernardes Gonçalo J L GJL Domingos Ana I AI
Cell metabolism 20200512 6
Anti-obesity drugs in the amphetamine (AMPH) class act in the brain to reduce appetite and increase locomotion. They are also characterized by adverse cardiovascular effects with origin that, despite absence of any in vivo evidence, is attributed to a direct sympathomimetic action in the heart. Here, we show that the cardiac side effects of AMPH originate from the brain and can be circumvented by PEGylation (PEGyAMPH) to exclude its central action. PEGyAMPH does not enter the brain and facilitat ...[more]
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