Accelerated MRI-predicted brain ageing and its associations with cardiometabolic and brain disorders.
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ABSTRACT:
SUBMITTER: Kolbeinsson A
PROVIDER: S-EPMC7672070 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Accelerated MRI-predicted brain ageing and its associations with cardiometabolic and brain disorders.
Kolbeinsson Arinbjörn A Filippi Sarah S Panagakis Yannis Y Matthews Paul M PM Elliott Paul P Dehghan Abbas A Tzoulaki Ioanna I
Scientific reports 20201117 1
Brain structure in later life reflects both influences of intrinsic aging and those of lifestyle, environment and disease. We developed a deep neural network model trained on brain MRI scans of healthy people to predict "healthy" brain age. Brain regions most informative for the prediction included the cerebellum, hippocampus, amygdala and insular cortex. We then applied this model to data from an independent group of people not stratified for health. A phenome-wide association analysis of over ...[more]
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