Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC7672426 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Yang Yenan Y Zhu Xiaoli X Jia Xiang X Hou Wanwan W Zhou Guoqiang G Ma Zhangjing Z Yu Bin B Pi Yan Y Zhang Xumin X Wang Jingqiang J Wang Gang G
Nucleic acids research 20201101 20
Msh homeobox (Msx) is a subclass of homeobox transcriptional regulators that control cell lineage development, including the early stage of vertebrate limb development, although the underlying mechanisms are not clear. Here, we demonstrate that Msx1 promotes the proliferation of myoblasts and mesenchymal stem cells (MSCs) by enhancing mitogen-activated protein kinase (MAPK) signaling. Msx1 directly binds to and upregulates the expression of fibroblast growth factor 9 (Fgf9) and Fgf18. Accordingl ...[more]