Ontology highlight
ABSTRACT:
SUBMITTER: Bouchal T
PROVIDER: S-EPMC7672436 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Bouchal Tomáš T Durník Ivo I Illík Viktor V Réblová Kamila K Kulhánek Petr P
Nucleic acids research 20201101 20
Mismatch repair is a highly conserved cellular pathway responsible for repairing mismatched dsDNA. Errors are detected by the MutS enzyme, which most likely senses altered mechanical property of damaged dsDNA rather than a specific molecular pattern. While the curved shape of dsDNA in crystallographic MutS/DNA structures suggests the role of DNA bending, the theoretical support is not fully convincing. Here, we present a computational study focused on a base-pair opening into the minor groove, a ...[more]