Ontology highlight
ABSTRACT:
SUBMITTER: van Aalten DM
PROVIDER: S-EPMC18368 | biostudies-literature | 1999 Oct
REPOSITORIES: biostudies-literature
van Aalten D M DM Erlanson D A DA Verdine G L GL Joshua-Tor L L
Proceedings of the National Academy of Sciences of the United States of America 19991001 21
The response of double-helical DNA to torsional stress may be a driving force for many processes acting on DNA. The 1.55-A crystal structure of a duplex DNA oligonucleotide d(CCAGGCCTGG)(2) with an engineered crosslink in the minor groove between the central guanine bases depicts how the duplex can accommodate such torsional stress. We have captured in the same crystal two rather different conformational states. One duplex contains a strained crosslink that is stabilized by calcium ion binding i ...[more]