Ontology highlight
ABSTRACT:
SUBMITTER: Dalskov L
PROVIDER: S-EPMC7672473 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Dalskov Louise L Narita Ryo R Andersen Line L LL Jensen Nanna N Assil Sonia S Kristensen Kennith H KH Mikkelsen Jacob G JG Fujita Takashi T Mogensen Trine H TH Paludan Søren R SR Hartmann Rune R
Nucleic acids research 20201101 20
IRF3 and IRF7 are critical transcription factors in the innate immune response. Their activation is controlled by phosphorylation events, leading to the formation of homodimers that are transcriptionally active. Phosphorylation occurs when IRF3 is recruited to adaptor proteins via a positively charged surface within the regulatory domain of IRF3. This positively charged surface also plays a crucial role in forming the active homodimer by interacting with the phosphorylated sites stabilizing the ...[more]