Dataset Information

BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils.

ABSTRACT: The tuberculosis vaccine bacillus Calmette-Guérin (BCG) protects against some heterologous infections, probably via induction of non-specific innate immune memory in monocytes and natural killer (NK) cells, a process known as trained immunity. Recent studies have revealed that the induction of trained immunity is associated with a bias toward granulopoiesis in bone marrow hematopoietic progenitor cells, but it is unknown whether BCG vaccination also leads to functional reprogramming of mature neutrophils. Here, we show that BCG vaccination of healthy humans induces long-lasting changes in neutrophil phenotype, characterized by increased expression of activation markers and antimicrobial function. The enhanced function of human neutrophils persists for at least 3 months after vaccination and is associated with genome-wide epigenetic modifications in trimethylation at histone 3 lysine 4. Functional reprogramming of neutrophils by the induction of trained immunity might offer novel therapeutic strategies in clinical conditions that could benefit from modulation of neutrophil effector function.

SUBMITTER: Moorlag SJCFM

PROVIDER: S-EPMC7672522 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils.

Moorlag Simone J C F M SJCFM Rodriguez-Rosales Yessica Alina YA Gillard Joshua J Fanucchi Stephanie S Theunissen Kate K Novakovic Boris B de Bont Cynthia M CM Negishi Yutaka Y Fok Ezio T ET Kalafati Lydia L Verginis Panayotis P Mourits Vera P VP Koeken Valerie A C M VACM de Bree L Charlotte J LCJ Pruijn Ger J M GJM Fenwick Craig C van Crevel Reinout R Joosten Leo A B LAB Joosten Irma I Koenen Hans H Mhlanga Musa M MM Diavatopoulos Dimitri A DA Chavakis Triantafyllos T Netea Mihai G MG

Cell reports 20201101 7

The tuberculosis vaccine bacillus Calmette-Guérin (BCG) protects against some heterologous infections, probably via induction of non-specific innate immune memory in monocytes and natural killer (NK) cells, a process known as trained immunity. Recent studies have revealed that the induction of trained immunity is associated with a bias toward granulopoiesis in bone marrow hematopoietic progenitor cells, but it is unknown whether BCG vaccination also leads to functional reprogramming of mature ne ...[more]

PMID: 33207187

Similar Datasets

Project description:In this paper, we review the published evidence about the long-term efficacy of the available human papillomavirus (HPV) vaccines and their safety profile. Two prophylactic HPV vaccines - bivalent (bHPV) and quadrivalent (qHPV) - are now available, and vaccination programs are being widely implemented, primarily targeting adolescent girls. Efficacy has been widely demonstrated for both vaccines. Since the risk of HPV exposure potentially persists throughout a woman's sexual life, vaccine duration of protection is critical to overall effectiveness. Interpreting the results of long-term efficacy studies for the two HPV vaccines can be puzzling, due to the heterogeneity of studies, different methods used in the assessment of immunogenicity, histopathological and virological end points, and statistical power issues. Moreover, an immunologic correlate of protection has not yet been established, and it is unknown whether higher antibody levels will really result in a longer duration of protection. Disease prevention remains the most important measure of long-term duration of vaccine efficacy. To date, the longest follow-up of an HPV vaccine has been 9.4 years for the bHPV vaccine. Long-term follow-up for qHPV vaccine goes up to 8 years. The vaccine continues to be immunogenic and well tolerated up to 9 years following vaccination. All randomized controlled clinical trials of the bHPV and the qHPV vaccines provide evidence of an excellent safety profile. The most common complaint reported is pain in the injection site, which is self-limiting and spontaneously resolved. The incidence of systemic adverse events (AEs), serious AEs, and discontinuations due to a serious AE reported in clinical studies are similar between the two vaccines and their control groups. In particular, no increased risk of autoimmune disease has been shown among HPV-vaccinated subjects in long-term observation studies. As these are crucial topics in HPV vaccination, it is important to establish systems for continued monitoring of vaccine immunogenicity, efficacy, and safety over time.

Dataset Information

BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils.

Publications

BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets