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Gamma activity accelerates during prefrontal development.

ABSTRACT: Gamma oscillations are a prominent activity pattern in the cerebral cortex. While gamma rhythms have been extensively studied in the adult prefrontal cortex in the context of cognitive (dys)functions, little is known about their development. We addressed this issue by using extracellular recordings and optogenetic stimulations in mice across postnatal development. We show that fast rhythmic activity in the prefrontal cortex becomes prominent during the second postnatal week. While initially at about 15 Hz, fast oscillatory activity progressively accelerates with age and stabilizes within gamma frequency range (30-80 Hz) during the fourth postnatal week. Activation of layer 2/3 pyramidal neurons drives fast oscillations throughout development, yet the acceleration of their frequency follows similar temporal dynamics as the maturation of fast-spiking interneurons. These findings uncover the development of prefrontal gamma activity and provide a framework to examine the origin of abnormal gamma activity in neurodevelopmental disorders.

SUBMITTER: Bitzenhofer SH

PROVIDER: S-EPMC7673781 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Gamma activity accelerates during prefrontal development.

Bitzenhofer Sebastian H SH Pöpplau Jastyn A JA Hanganu-Opatz Ileana I

eLife 20201118

Gamma oscillations are a prominent activity pattern in the cerebral cortex. While gamma rhythms have been extensively studied in the adult prefrontal cortex in the context of cognitive (dys)functions, little is known about their development. We addressed this issue by using extracellular recordings and optogenetic stimulations in mice across postnatal development. We show that fast rhythmic activity in the prefrontal cortex becomes prominent during the second postnatal week. While initially at a ...[more]

PMID: 33206597

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Project description:The ability to execute a motor plan involves spatiotemporally precise oscillatory activity in primary motor (M1) regions, in concert with recruitment of "higher order" attentional mechanisms for orienting toward current task goals. While current evidence implicates gamma oscillatory activity in M1 as central to the execution of a movement, far less is known about top-down attentional modulation of this response. Herein, we utilized magnetoencephalography (MEG) during a Posner attention-reorienting task to investigate top-down modulation of M1 gamma responses by frontal attention networks in 63 healthy adult participants. MEG data were evaluated in the time-frequency domain and significant oscillatory responses were imaged using a beamformer. Robust increases in theta activity were found in bilateral inferior frontal gyri (IFG), with significantly stronger responses evident in trials that required attentional reorienting relative to those that did not. Additionally, strong gamma oscillations (60-80?Hz) were detected in M1 during movement execution, with similar responses elicited irrespective of attentional reorienting. Whole-brain voxel-wise correlations between validity difference scores (i.e., attention reorienting trials-nonreorienting trials) in frontal theta activity and movement-locked gamma oscillations revealed a robust relationship in the contralateral sensorimotor cortex, supplementary motor area, and right cerebellum, suggesting modulation of these sensorimotor network gamma responses by attentional reorienting. Importantly, the validity difference effect in this distributed motor network was predictive of overall motor function measured outside the scanner and further, based on a mediation analysis this relationship was fully mediated by the reallocation response in the right IFG. These data are the first to characterize the top-down modulation of movement-related gamma responses during attentional reorienting and movement execution.

Dataset Information

Gamma activity accelerates during prefrontal development.

Publications

Gamma activity accelerates during prefrontal development.

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