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Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.

ABSTRACT: Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant.

SUBMITTER: Volz E

PROVIDER: S-EPMC7674007 | biostudies-literature |

REPOSITORIES: biostudies-literature

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SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility.

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| S-EPMC9671695 | biostudies-literature

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SARS-CoV-2 spike protein S:D614G + S:A222V variant

Project description: Not available

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D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization.

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SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity.

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Single particle cryo EM dataset of SARS-CoV-2 Spike protein with D614G substitution

Project description: Not available

| EMPIAR-10725 | biostudies-other

Detection of SARS-CoV-2 spike protein D614G mutation by qPCR-HRM analysis.

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| S-EPMC8420086 | biostudies-literature

SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity.

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| S-EPMC7870668 | biostudies-literature

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