Outcomes and patterns of radiation associated brain image changes after proton therapy for head and neck skull base cancers.

ABSTRACT:

Background and purpose

To characterize patterns and outcomes of brain MR image changes after proton therapy (PT) for skull base head and neck cancer (HNC).

Material and methods

Post-treatment MRIs ≥6 months were reviewed for radiation-associated image changes (RAIC) in 127 patients. All patients had received at least a point dose of 40 Gy(RBE) to the brain. The MRIs were rigidly registered to planning CTs and RAIC lesions were contoured both on T1 weighted (post-contrast) and T2 weighted sequences, and dose-volume parameters extracted. Probability of RAIC was calculated using multistate survival analysis. Univariate/multivariate analyses were performed using Cox Regression. Recursive partitioning analysis was used to investigate dose-volume correlates of RAIC development.

SUBMITTER: Engeseth GM 

PROVIDER: S-EPMC7674217 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature