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Preregistered Direct Replication of "Sick Body, Vigilant Mind: The Biological Immune System Activates the Behavioral Immune System".

ABSTRACT: The tendency to attend to and avoid cues to pathogens varies across individuals and contexts. Researchers have proposed that this variation is partially driven by immunological vulnerability to infection, though support for this hypothesis is equivocal. One key piece of evidence (Miller & Maner, 2011) shows that participants who have recently been ill-and hence may have a reduced ability to combat subsequent infection-allocate more attention to faces with infectious-disease cues than do participants who have not recently been ill. The current article describes a direct replication of this study using a sample of 402 individuals from the University of Michigan, the University of Glasgow, and Vrije Universiteit Amsterdam-more than 4 times the sample size of the original study. No effect of illness recency on attentional bias for disfigured faces emerged. Though it did not support the original finding, this replication provides suggestions for future research on the psychological underpinnings of pathogen avoidance.

SUBMITTER: Tybur JM

PROVIDER: S-EPMC7675771 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Preregistered Direct Replication of "Sick Body, Vigilant Mind: The Biological Immune System Activates the Behavioral Immune System".

Tybur Joshua M JM Jones Benedict C BC DeBruine Lisa M LM Ackerman Joshua M JM Fasolt Vanessa V

Psychological science 20201020 11

The tendency to attend to and avoid cues to pathogens varies across individuals and contexts. Researchers have proposed that this variation is partially driven by immunological vulnerability to infection, though support for this hypothesis is equivocal. One key piece of evidence (Miller & Maner, 2011) shows that participants who have recently been ill-and hence may have a reduced ability to combat subsequent infection-allocate more attention to faces with infectious-disease cues than do particip ...[more]

PMID: 33079639

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Project description:Psychological and health-restorative benefits of mind-body therapies have been investigated, but their impact on the immune system remain less defined.To conduct the first comprehensive review of available controlled trial evidence to evaluate the effects of mind-body therapies on the immune system, focusing on markers of inflammation and anti-viral related immune responses.Data sources included MEDLINE, CINAHL, SPORTDiscus, and PsycINFO through September 1, 2013. Randomized controlled trials published in English evaluating at least four weeks of Tai Chi, Qi Gong, meditation, or Yoga that reported immune outcome measures were selected. Studies were synthesized separately by inflammatory (n?=?18), anti-viral related immunity (n?=?7), and enumerative (n?=?14) outcomes measures. We performed random-effects meta-analyses using standardized mean difference when appropriate.Thirty-four studies published in 39 articles (total 2, 219 participants) met inclusion criteria. For inflammatory measures, after 7 to 16 weeks of mind-body intervention, there was a moderate effect on reduction of C-reactive protein (effect size [ES], 0.58; 95% confidence interval [CI], 0.04 to 1.12), a small but not statistically significant reduction of interleukin-6 (ES, 0.35; 95% CI, -0.04 to 0.75), and negligible effect on tumor necrosis factor-? (ES, 0.21; 95% CI, -0.15 to 0.58). For anti-viral related immune and enumerative measures, there were negligible effects on CD4 counts (ES, 0.15; 95% CI, -0.04 to 0.34) and natural killer cell counts (ES, 0.12, 95% CI -0.21 to 0.45). Some evidence indicated mind-body therapies increase immune responses to vaccination.Mind-body therapies reduce markers of inflammation and influence virus-specific immune responses to vaccination despite minimal evidence suggesting effects on resting anti-viral or enumerative measures. These immunomodulatory effects, albeit incomplete, warrant further methodologically rigorous studies to determine the clinical implications of these findings for inflammatory and infectious disease outcomes.

Dataset Information

Preregistered Direct Replication of "Sick Body, Vigilant Mind: The Biological Immune System Activates the Behavioral Immune System".

Publications

Preregistered Direct Replication of "Sick Body, Vigilant Mind: The Biological Immune System Activates the Behavioral Immune System".

Similar Datasets

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