Serum trace metal association with response to erythropoiesis stimulating agents in incident and prevalent hemodialysis patients.

ABSTRACT: Alterations in hemodialysis patients' serum trace metals have been documented. Early studies addressing associations levels of serum trace metals with erythropoietic responses and/or hematocrit generated mixed results. These studies were conducted prior to current approaches for erythropoiesis stimulating agent (ESA) drug dosing guidelines or without consideration of inflammation markers (e.g. hepcidin) important for regulation of iron availability. This study sought to determine if the serum trace metal concentrations of incident or chronic hemodialysis patients associated with the observed ESA response variability and with consideration to ESA dose response, hepcidin, and high sensitivity C-reactive protein levels. Inductively-coupled plasma-mass spectrometry was used to measure 14 serum

SUBMITTER: Brier ME 

PROVIDER: S-EPMC7677396 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature