Selenium Associates With Response to Erythropoiesis-Stimulating Agents in Hemodialysis Patients.

ABSTRACT:

Introduction

Impaired response to erythropoiesis-stimulating agents (ESAs) is associated with increased mortality in patients with end-stage kidney disease. However, the underlying mechanisms are not fully elucidated. Accumulating data reveal that selenium (Se), a trace element, plays a key role in stress erythropoiesis and erythrocyte homeostasis. We evaluated the relationship between serum Se levels and the response to ESAs in hemodialysis patients.

Methods

In this cross-sectional study, we determined serum Se levels in 173 hemodialysis patients. We analyzed the association of serum Se with ESA responsiveness, as defined by ESA resistance index.

Results

Of the study participants, 50% had lower Se levels than the population-based reference values. We found that serum

SUBMITTER: Yasukawa M 

PROVIDER: S-EPMC9263417 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature