Mediation by differential DNA methylation of known associations between single nucleotide polymorphisms and bladder cancer risk.

ABSTRACT:

Background

Though bladder cancer has been the subject of many well-powered genome-wide association studies, the mechanisms involving bladder-cancer-associated single nucleotide polymorphisms (SNPs) remain largely unknown. This study focuses on rs798766, rs401681, rs2294008, and rs8102137, which have been associated with bladder cancer and are also cis-acting methylation quantitative loci (mQTL).

Methods

Among 412 bladder cancer cases and 424 controls from the Women's Health Initiative (WHI), we assessed whether the effects of these SNPs on bladder cancer are mediated through proximal DNA methylation changes in pre-diagnostic blood at mQTL-associated CpG sites, which we refer to as natural indirect effects (NIEs). We used a multiple-mediator mediation model for each of the fo

SUBMITTER: Jordahl KM 

PROVIDER: S-EPMC7678190 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature