Ontology highlight
ABSTRACT:
SUBMITTER: Park JM
PROVIDER: S-EPMC7678296 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Park Jung Min JM Kim Yoon-Jae YJ Park Soeun S Park Minsu M Farrand Lee L Nguyen Cong-Truong CT Ann Jihyae J Nam Gibeom G Park Hyun-Ju HJ Lee Jeewoo J Kim Ji Young JY Seo Jae Hong JH
Molecular cancer 20201120 1
Trastuzumab resistance in HER2-positive breast cancer is associated with a poorer prognosis. HSP90 is thought to play a major role in such resistance, but N-terminal inhibitors of this target have had little success. We sought to investigate the utility of NCT-547, a novel, rationally-designed C-terminal HSP90 inhibitor in the context of overcoming trastuzumab resistance. NCT-547 treatment significantly induced apoptosis without triggering the heat shock response (HSR), accompanied by caspase-3/ ...[more]