Ontology highlight
ABSTRACT:
SUBMITTER: Sorensen A
PROVIDER: S-EPMC7678323 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Alzheimer's research & therapy 20201119 1
<h4>Background</h4>Amyloid-β (Aβ) PET is an established predictor of conversion from mild cognitive impairment (MCI) to Alzheimer's dementia (AD). We compared three PET (including an approach based on voxel-wise Cox regression) and one cerebrospinal fluid (CSF) outcome measures in their predictive power.<h4>Methods</h4>Datasets were retrieved from the ADNI database. In a training dataset (N = 159), voxel-wise Cox regression and principal component analyses were used to identify conversion-relate ...[more]