Dataset Information

Performance of serum apolipoprotein-A1 as a sentinel of Covid-19.

ABSTRACT: Background:Since 1920, a decrease in serum cholesterol has been identified as a marker of severe pneumonia. We have assessed the performance of serum apolipoprotein-A1, the main transporter of HDL-cholesterol, to identify the early spread of coronavirus disease 2019 (Covid-19) in the general population and its diagnostic performance for the Covid-19.

Methods:We compared the daily mean serum apolipoprotein-A1 during the first 34 weeks of 2020 in a population that is routinely followed for a risk of liver fibrosis risk in the USA (212,297 serum) and in France (20,652 serum) in relation to a local increase in confirmed cases, and in comparison to the same period in 2019 (266,976 and 28,452 serum, respectively). We prospectively assessed the sensitivity of this marker in an observational study of 136 consecutive hospitalized cases and retrospectively evaluated its specificity in 7,481 controls representing the general population.

Results:The mean serum apolipoprotein-A1 levels in the survey populations began decreasing in January 2020, compared to the same period in 2019. This decrease was highly correlated with the daily increase in confirmed Covid-19 cases in the following 34 weeks, both in France and USA, including the June and mid-July recovery periods in France. Apolipoprotein-A1 at the 1.25 g/L cutoff had a sensitivity of 90.6% (95%CI84.2-95.1) and a specificity of 96.1% (95.7-96.6%) for the diagnosis of Covid-19. The area under the characteristics curve was 0.978 (0.957-0.988), and outperformed haptoglobin and liver function tests. The adjusted risk ratio of apolipoprotein-A1 for survival without transfer to intensive care unit was 5.61 (95%CI 1.02-31.0; P = 0.04).

Conclusion:Apolipoprotein-A1 could be a sentinel of the pandemic in existing routine surveillance of the general population. NCT01927133, CER-2020-14.

SUBMITTER: Poynard T

PROVIDER: S-EPMC7679025 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Performance of serum apolipoprotein-A1 as a sentinel of Covid-19.

Poynard Thierry T Deckmyn Olivier O Rudler Marika M Peta Valentina V Ngo Yen Y Vautier Mathieu M Akhavan Sepideh S Calvez Vincent V Franc Clemence C Castille Jean Marie JM Drane Fabienne F Sakka Mehdi M Bonnefont-Rousselot Dominique D Lacorte Jean Marc JM Saadoun David D Allenbach Yves Y Benveniste Olivier O Gandjbakhch Frederique F Mayaux Julien J Lucidarme Olivier O Fautrel Bruno B Ratziu Vlad V Housset Chantal C Thabut Dominique D Cacoub Patrice P

PloS one 20201120 11

<h4>Background</h4>Since 1920, a decrease in serum cholesterol has been identified as a marker of severe pneumonia. We have assessed the performance of serum apolipoprotein-A1, the main transporter of HDL-cholesterol, to identify the early spread of coronavirus disease 2019 (Covid-19) in the general population and its diagnostic performance for the Covid-19.<h4>Methods</h4>We compared the daily mean serum apolipoprotein-A1 during the first 34 weeks of 2020 in a population that is routinely follo ...[more]

PMID: 33216772

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Dataset Information

Performance of serum apolipoprotein-A1 as a sentinel of Covid-19.

Publications

Performance of serum apolipoprotein-A1 as a sentinel of Covid-19.

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