Ontology highlight
ABSTRACT:
SUBMITTER: Green JP
PROVIDER: S-EPMC7679132 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Green Jack P JP Swanton Tessa T Morris Lucy V LV El-Sharkawy Lina Y LY Cook James J Yu Shi S Beswick James J Adamson Antony D AD Humphreys Neil E NE Bryce Richard R Freeman Sally S Lawrence Catherine C Brough David D
eLife 20201120
The NLRP3 inflammasome is a multi-molecular protein complex that converts inactive cytokine precursors into active forms of IL-1β and IL-18. The NLRP3 inflammasome is frequently associated with the damaging inflammation of non-communicable disease states and is considered an attractive therapeutic target. However, there is much regarding the mechanism of NLRP3 activation that remains unknown. Chloride efflux is suggested as an important step in NLRP3 activation, but which chloride channels are i ...[more]