Ontology highlight
ABSTRACT:
SUBMITTER: Angeloni J
PROVIDER: S-EPMC7679379 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Angeloni Joseph J Dong Yuqing Y Wang Zeneng Z Cao Min M
Communications biology 20201120 1
Cyclic di-nucleotides are important secondary signaling molecules in bacteria that regulate a wide range of processes. In this study, we found that Caenorhabditis elegans can detect and are attracted to multiple signal molecules produced by Vibrio cholerae, specifically the 3',5'-cyclic diguanylate (c-di-GMP), even though this bacterium kills the host at a high rate. C-di-GMP is sensed through C. elegans olfactory AWC neurons, which then evokes a series of signal transduction pathways that lead ...[more]