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Bacterial second messenger 3',5'-cyclic diguanylate attracts Caenorhabditis elegans and suppresses its immunity.


ABSTRACT: Cyclic di-nucleotides are important secondary signaling molecules in bacteria that regulate a wide range of processes. In this study, we found that Caenorhabditis elegans can detect and are attracted to multiple signal molecules produced by Vibrio cholerae, specifically the 3',5'-cyclic diguanylate (c-di-GMP), even though this bacterium kills the host at a high rate. C-di-GMP is sensed through C. elegans olfactory AWC neurons, which then evokes a series of signal transduction pathways that lead to reduced activity of two key stress response transcription factors, SKN-1 and HSF-1, and weakened innate immunity. Taken together, our study elucidates the role of c-di-GMP in interkingdom communication. For C. elegans, bacterial c-di-GMP may serve as a cue that they can use to detect food. On the other hand, preexposure to low concentrations of c-di-GMP may impair their immune response, which could facilitate bacterial invasion and survival.

SUBMITTER: Angeloni J 

PROVIDER: S-EPMC7679379 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Bacterial second messenger 3',5'-cyclic diguanylate attracts Caenorhabditis elegans and suppresses its immunity.

Angeloni Joseph J   Dong Yuqing Y   Wang Zeneng Z   Cao Min M  

Communications biology 20201120 1


Cyclic di-nucleotides are important secondary signaling molecules in bacteria that regulate a wide range of processes. In this study, we found that Caenorhabditis elegans can detect and are attracted to multiple signal molecules produced by Vibrio cholerae, specifically the 3',5'-cyclic diguanylate (c-di-GMP), even though this bacterium kills the host at a high rate. C-di-GMP is sensed through C. elegans olfactory AWC neurons, which then evokes a series of signal transduction pathways that lead  ...[more]

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