Ontology highlight
ABSTRACT:
SUBMITTER: Dong Z
PROVIDER: S-EPMC7682896 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Dong Zhexu Z Dai Lei L Zhang Yong Y Fang Chao C Shi Gang G Chen Ye Y Li Junshu J Wang Qin Q Fu Jiamei J Yu Yan Y Wang Wenshuang W Cheng Lin L Liu Yi Y Lin Yi Y Wang Yuan Y Wang Qingnan Q Wang Huiling H Zhang Hantao H Zhang Yujing Y Su Xiaolan X Zhang Shuang S Wang Feng F Qiu Meng M Zhou Zongguang Z Deng Hongxin H
PLoS genetics 20201111 11
Tumor metastasis is the major cause of poor prognosis and mortality in colorectal cancer (CRC). However, early diagnosis of highly metastatic CRC is currently difficult. In the present study, we screened for a novel biomarker, GDNF family receptor alpha 1 (GFRA1) based on the expression and methylation data in CRC patients from The Cancer Genome Altlas (TCGA), followed by further analysis of the correlation between the GFRA1 expression, methylation, and prognosis of patients. Our results show DN ...[more]