Ontology highlight
ABSTRACT:
SUBMITTER: Eyboulet F
PROVIDER: S-EPMC7682988 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
eLife 20201123
Nuclear export of messenger RNAs (mRNAs) is intimately coupled to their synthesis. pre-mRNAs assemble into dynamic ribonucleoparticles as they are being transcribed, processed, and exported. The role of ubiquitylation in this process is increasingly recognized but, while a few E3 ligases have been shown to regulate nuclear export, evidence for deubiquitylases is currently lacking. Here we identified deubiquitylase Ubp15 as a regulator of nuclear export in <i>Saccharomyces cerevisiae.</i> Ubp15 i ...[more]