Ontology highlight
ABSTRACT:
SUBMITTER: Beke F
PROVIDER: S-EPMC7683743 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Nature communications 20201123 1
Regioselective vicinal diamination of carbon-carbon double bonds with two different amines is a synthetic challenge under transition metal-free conditions, especially for the synthesis of trifluoromethylated amines. However, the synthesis of ethylene diamines and fluorinated amine compounds is demanded, especially in the pharmaceutical sector. Herein, we demonstrate that the controllable double nucleophilic functionalization of an activated alkene synthon, originated from a trifluoropropenyliodo ...[more]