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α,α'-C-H Bond Difunctionalization of Unprotected Alicyclic Amines.

ABSTRACT: A simple one-pot procedure enables the sequential, regioselective, and diastereoselective introduction of the same or two different substituents to the α- and α'-positions of unprotected azacycles. Aryl, alkyl, and alkenyl substituents are introduced via their corresponding organolithium compounds. The scope of this transformation includes pyrrolidines, piperidines, azepanes, and piperazines.

SUBMITTER: Valles DA

PROVIDER: S-EPMC8609614 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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α,α'-C-H Bond Difunctionalization of Unprotected Alicyclic Amines.

Valles Daniel A DA Dutta Subhradeep S Paul Anirudra A Abboud Khalil A KA Ghiviriga Ion I Seidel Daniel D

Organic letters 20210729 16

A simple one-pot procedure enables the sequential, regioselective, and diastereoselective introduction of the same or two different substituents to the α- and α'-positions of unprotected azacycles. Aryl, alkyl, and alkenyl substituents are introduced via their corresponding organolithium compounds. The scope of this transformation includes pyrrolidines, piperidines, azepanes, and piperazines. ...[more]

PMID: 34323490

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