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Improved PET/MRI attenuation correction in the pelvic region using a statistical decomposition method on T2-weighted images.


ABSTRACT: BACKGROUND:Attenuation correction of PET/MRI is a remaining problem for whole-body PET/MRI. The statistical decomposition algorithm (SDA) is a probabilistic atlas-based method that calculates synthetic CTs from T2-weighted MRI scans. In this study, we evaluated the application of SDA for attenuation correction of PET images in the pelvic region. MATERIALS AND METHOD:Twelve patients were retrospectively selected from an ongoing prostate cancer research study. The patients had same-day scans of [11C]acetate PET/MRI and CT. The CT images were non-rigidly registered to the PET/MRI geometry, and PET images were reconstructed with attenuation correction employing CT, SDA-generated CT, and the built-in Dixon sequence-based method of the scanner. The PET images reconstructed using CT-based attenuation correction were used as ground truth. RESULTS:The mean whole-image PET uptake error was reduced from - 5.4% for Dixon-PET to - 0.9% for SDA-PET. The prostate standardized uptake value (SUV) quantification error was significantly reduced from - 5.6% for Dixon-PET to - 2.3% for SDA-PET. CONCLUSION:Attenuation correction with SDA improves quantification of PET/MR images in the pelvic region compared to the Dixon-based method.

SUBMITTER: Wallsten E 

PROVIDER: S-EPMC7683750 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Improved PET/MRI attenuation correction in the pelvic region using a statistical decomposition method on T2-weighted images.

Wallstén Elin E   Axelsson Jan J   Jonsson Joakim J   Karlsson Camilla Thellenberg CT   Nyholm Tufve T   Larsson Anne A  

EJNMMI physics 20201123 1


<h4>Background</h4>Attenuation correction of PET/MRI is a remaining problem for whole-body PET/MRI. The statistical decomposition algorithm (SDA) is a probabilistic atlas-based method that calculates synthetic CTs from T2-weighted MRI scans. In this study, we evaluated the application of SDA for attenuation correction of PET images in the pelvic region.<h4>Materials and method</h4>Twelve patients were retrospectively selected from an ongoing prostate cancer research study. The patients had same-  ...[more]

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