Association between five types of Tumor Necrosis Factor-? gene polymorphism and hepatocellular carcinoma risk: a meta-analysis.

ABSTRACT: BACKGROUND:Research focusing on the relationship between five types of tumor necrosis factor-alpha (TNF-?) SNPs and the risk of hepatocellular carcinoma (HCC) were still controversial. Hereby, we performed a meta-analysis to determine the association between TNF-? promoter SNPs: -1031?T/C, -?863 C/A, -?857 C/T, -?308?G/A, and?-?238?G/A with HCC risk. METHODS:We interrogated articles from journal database: PubMed, Pro-Quest, EBSCO, Science Direct, and Springer to determine the relationship between five types of SNPs in TNF-? gene with HCC risk. RevMan 5.3 software was used for analysis in fixed/random effect models. RESULTS:This meta-analysis included 23 potential articles from 2004 to 2018 with 3237 HCC cases and 4843 controls. We found that SNP -?863 C/A were associated with a significantly increased HCC risk (A vs C, OR?=?1.31, 95% CI?=?1.03-1.67). Similar results were obtained in -?857 C/T (TT/CT vs CC, OR?=?1.31, 95% CI?=?1.06-1.62), -?308?G/A (AA vs GG, OR?=?3.14, 95% CI?=?2.06-4.79), and?-?238?G/A (AA vs GG, OR?=?3.87, 95% CI?=?1.32-11.34). While no associations were observed between SNP TNF-? -?1031?T/C and HCC risk. CONCLUSIONS:The present meta-analysis showed that TNF? SNPs -863C/A, -?857 C/T, -?308?G/A, and?-?238?G/A were associated with the risk of HCC.

SUBMITTER: Wungu CDK 

PROVIDER: S-EPMC7686711 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature