Dataset Information

Association between five types of Tumor Necrosis Factor-? gene polymorphism and hepatocellular carcinoma risk: a meta-analysis.

ABSTRACT: BACKGROUND:Research focusing on the relationship between five types of tumor necrosis factor-alpha (TNF-?) SNPs and the risk of hepatocellular carcinoma (HCC) were still controversial. Hereby, we performed a meta-analysis to determine the association between TNF-? promoter SNPs: -1031?T/C, -?863 C/A, -?857 C/T, -?308?G/A, and?-?238?G/A with HCC risk. METHODS:We interrogated articles from journal database: PubMed, Pro-Quest, EBSCO, Science Direct, and Springer to determine the relationship between five types of SNPs in TNF-? gene with HCC risk. RevMan 5.3 software was used for analysis in fixed/random effect models. RESULTS:This meta-analysis included 23 potential articles from 2004 to 2018 with 3237 HCC cases and 4843 controls. We found that SNP -?863 C/A were associated with a significantly increased HCC risk (A vs C, OR?=?1.31, 95% CI?=?1.03-1.67). Similar results were obtained in -?857 C/T (TT/CT vs CC, OR?=?1.31, 95% CI?=?1.06-1.62), -?308?G/A (AA vs GG, OR?=?3.14, 95% CI?=?2.06-4.79), and?-?238?G/A (AA vs GG, OR?=?3.87, 95% CI?=?1.32-11.34). While no associations were observed between SNP TNF-? -?1031?T/C and HCC risk. CONCLUSIONS:The present meta-analysis showed that TNF? SNPs -863C/A, -?857 C/T, -?308?G/A, and?-?238?G/A were associated with the risk of HCC.

SUBMITTER: Wungu CDK

PROVIDER: S-EPMC7686711 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Association between five types of Tumor Necrosis Factor-α gene polymorphism and hepatocellular carcinoma risk: a meta-analysis.

Wungu Citrawati Dyah Kencono CDK Ariyanto Fis Citra FC Prabowo Gwenny Ichsan GI Soetjipto Handajani Retno R

BMC cancer 20201123 1

<h4>Background</h4>Research focusing on the relationship between five types of tumor necrosis factor-alpha (TNF-α) SNPs and the risk of hepatocellular carcinoma (HCC) were still controversial. Hereby, we performed a meta-analysis to determine the association between TNF-α promoter SNPs: -1031 T/C, - 863 C/A, - 857 C/T, - 308 G/A, and - 238 G/A with HCC risk.<h4>Methods</h4>We interrogated articles from journal database: PubMed, Pro-Quest, EBSCO, Science Direct, and Springer to determine the rela ...[more]

PMID: 33228594

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Project description:AimTo investigate associations between the tumor necrosis factor alpha (TNF-α) -1031 T>C, -863 C>A, -857 C>T, -308 G>A, and -238 G>A polymorphisms and HCC in Korea.MethodsHepatocellular carcinoma (HCC) cases were diagnosed at CHA Bundang Medical Center from June 1996 to August 2008. The association between TNF-α polymorphisms and HCC was analyzed in 157 HCC patients and 201 controls using a polymerase chain reaction-restriction fragment length polymorphism assay. We investigated five TNF-α polymorphisms, which are TNF-α -1031 T>C, -863 C>A, -857 C>T, -308 G>A, and -238 G>A. The TNF-α genotype frequencies, genotype combinations and haplotypes were analyzed to disclose the association with HCC.ResultsNone of the TNF-α polymorphisms was significantly associated with HCC. However, nine genotype combinations had associations with increased likelihood of HCC. Among them, TNF-α -1031/-857/-238 TT/CC/GA (AOR = 18.849, 95%CI: 2.203-161.246, P = 0.007), TNF-α -1031/-308/-238 TT/GG/GA (AOR = 26.956, 95%CI: 3.071-236.584, P = 0.003), and TNF-α -1031/-238 TT/GA (AOR = 21.576, 95%CI: 2.581-180.394, P = 0.005) showed marked association with HCC. There were five haplotypes of TNF-α polymorphisms which were significantly associated with HCC. They are TNF-α -1031/-863/-857/-308/-238 T-C-C-G-A (OR = 25.824, 95%CI: 1.491-447.223, P = 0.0005), TNF-α -1031/-857/-308/-238 T-C-G-A (OR = 12.059, 95%CI: 2.747-52.950, P < 0.0001), TNF-α -1031/-857/-238 T-C-A (OR = 10.696, 95%CI: 2.428-47.110, P = 0.0001), TNF-α -1031/-308/-238 T-G-A (OR = 7.556, 95%CI: 2.173-26.280, P = 0.0002) and TNF-α -1031/-238 T-A (OR = 10.865, 95%CI: 2.473-47.740, P = 0.0001). Moreover, HCC Okuda stage III cases with the TNF-α -1031 CC genotype had better survival than those with the TT genotype (AOR = 5.795, 95%CI: 1.145-29.323).ConclusionAlthough no single TNF-α polymorphism is associated with HCC in this study, some TNF-α genotype combinations and haplotypes are associated with HCC. In addition, HCC Okuda stage III cases with the TNF-α -1031 TT genotype may have a better prognosis than those with the CC genotype.

Dataset Information

Association between five types of Tumor Necrosis Factor-? gene polymorphism and hepatocellular carcinoma risk: a meta-analysis.

Publications

Association between five types of Tumor Necrosis Factor-α gene polymorphism and hepatocellular carcinoma risk: a meta-analysis.

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