Dataset Information

The effect of acupuncture stimulation on alleviating emotional changes due to acute alcohol administration and the possibility of sigma₁ receptor involvement.

ABSTRACT:

Background

Most ETOH addiction preclinical studies have focused on the rewards of chronic ETOH self-administration or the ETOH reinstatement model. Acute ETOH administration studies are scarce despite the potential of ETOH to cause sedation, intoxication and reduced acute functional tolerance. Here, we established a rat model of acute ETOH administration induced by an intraperitoneal injection of 1?g/kg ethanol and assessed the similarities in physiological and behavioral effects between acupuncture and Sigma1 R antagonists.

Methods

Male Wistar rats (300-330?g) received pretreatment with (1) saline injection, (2) saline?+?mechanical stimulation using a mechanical acupuncture instrument (MAI) for acupuncture at the Shenmen (HT7), (3) ETOH (1?g/kg) injection, (4) ETOH?+?HT7, or (5) the selective ?₁ R antagonist BD 1047 (3, 10, or 30?mg/kg, intraperitoneal (IP) injection). ETOH (1?g/kg) or saline was IP injected after 10?min. Then, ETOH-induced immobility was evaluated in an open field arena, ultrasonic vocalizations (USVs) indicating ethanol-induced emotional changes were recorded in a recording chamber, and the rats were sacrificed for the analysis of protein levels of ?₁ R in several regions of the brain.

Results

Acute ethanol exposure increased the immobile time, 22-kHz USVs, and protein levels of ?₁ R in the ventral tegmental area (VTA). However, pretreatment with acupuncture at HT7 induced recovery of immobile time, reduced 22-kHz USVs, and regulated the protein levels of ?1 R in the VTA. These effects have similarities with IP injection of BD 1047 (10?mg/kg).

Conclusion

This study showed that acupuncture at HT7 regulates immobility and 22-kHz USVs via Sigma₁ R in the VTA upon acute ETOH exposure.

SUBMITTER: Seo SY

PROVIDER: S-EPMC7689173 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Publications

The effect of acupuncture stimulation on alleviating emotional changes due to acute alcohol administration and the possibility of sigma<sub>1</sub> receptor involvement.

Seo Su Yeon SY Kim Soo Phil SP Bang Se Kyun SK Kang Suk Yun SY Cho Seong Jin SJ Choi Kwang-Ho KH Ryu Yeonhee Y

Integrative medicine research 20200812 2

<h4>Background</h4>Most ETOH addiction preclinical studies have focused on the rewards of chronic ETOH self-administration or the ETOH reinstatement model. Acute ETOH administration studies are scarce despite the potential of ETOH to cause sedation, intoxication and reduced acute functional tolerance. Here, we established a rat model of acute ETOH administration induced by an intraperitoneal injection of 1 g/kg ethanol and assessed the similarities in physiological and behavioral effects between ...[more]

PMID: 33384922

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Dataset Information

The effect of acupuncture stimulation on alleviating emotional changes due to acute alcohol administration and the possibility of sigma₁ receptor involvement.

Background

Methods

Results

Conclusion

Publications

The effect of acupuncture stimulation on alleviating emotional changes due to acute alcohol administration and the possibility of sigma<sub>1</sub> receptor involvement.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

The effect of acupuncture stimulation on alleviating emotional changes due to acute alcohol administration and the possibility of sigma1 receptor involvement.

Background

Methods

Results

Conclusion

Publications

The effect of acupuncture stimulation on alleviating emotional changes due to acute alcohol administration and the possibility of sigma<sub>1</sub> receptor involvement.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

The effect of acupuncture stimulation on alleviating emotional changes due to acute alcohol administration and the possibility of sigma₁ receptor involvement.