Proteomics

Dataset Information

0

Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis


ABSTRACT: Ginseng (Panax ginseng Meyer) is commonly used as an herbal remedy worldwide. Few studies have explored the possible physiological changes in the liver although patients often self-medicate with ginseng preparations, which may lead to exceeding the recommended dose for long-term administration. Here, we analyzed changes in the hepatic proteins of mouse livers using quantitative proteomics after sub-chronic administration of Korean red ginseng (KRG) extract (control group and 0.5, 1.0, and 2.0 g/kg KRG) using tandem mass tag (TMT) 6‐plex technology. The 1.0 and 2.0 g/kg KRG groups exhibited signs of liver injury, including increased levels of aspartate transaminase (AST) and alanine aminotransferase (ALT) in the serum. Furthermore, serum glucose levels were significantly higher following KRG administration compared with the control group. Based on the upregulated proteins found in the proteomic analysis, we found that increased cystathionin beta-synthase (CBS) and cystathionine gamma-lyase (CSE) levels promoted greater hydrogen sulfide (HRR2RRS) synthesis in the liver. This investigation provides novel evidence that14T sub-chronic administration of 4T14TKRG can elevate HRR2RRS production by increasing protein expression of CBS and CSE in the liver.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Ann-Yae Na  

LAB HEAD: Sangkyu Lee

PROVIDER: PXD023731 | Pride | 2021-09-10

REPOSITORIES: Pride

altmetric image

Publications

Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis.

Na Ann-Yae AY   Jo Jung Jae JJ   Kwon Oh Kwang OK   Cho Piljoung P   Gao Yan Y   Kim Ju-Hyun JH   Kim Kyu Min KM   Ki Sung Hwan SH   Lee Sangkyu S  

Scientific reports 20210611 1


Ginseng (Panax ginseng Meyer) is commonly used as an herbal remedy worldwide. Few studies have explored the possible physiological changes in the liver although patients often self-medicate with ginseng preparations, which may lead to exceeding the recommended dose for long-term administration. Here, we analyzed changes in the hepatic proteins of mouse livers using quantitative proteomics after sub-chronic administration of Korean red ginseng (KRG) extract (control group and 0.5, 1.0, and 2.0 g/  ...[more]

Similar Datasets

2022-04-14 | GSE200397 | GEO
| 106072 | ecrin-mdr-crc
2015-07-22 | GSE59241 | GEO
2017-07-10 | PXD006313 | Pride
2015-07-22 | E-GEOD-59241 | biostudies-arrayexpress
| 2143514 | ecrin-mdr-crc
2016-08-09 | E-GEOD-75277 | biostudies-arrayexpress
2023-03-11 | PXD032036 | Pride
2023-09-21 | PXD028602 | Pride
2023-03-11 | PXD038524 | Pride