Development and validation of a prognostic model for adult patients with acute myeloid leukaemia.

ABSTRACT:

Background

The high heterogeneity of acute myeloid leukaemia (AML) reflected in the patient- and disease-related factors accounts for the unsatisfactory prognosis despite the introduction of novel therapeutic approaches and drugs in recent years.

Methods

In the development set (n = 412), parameters including age, hematopoietic cell transplantation-comorbidity index, white blood cell count, hemoglobin, biallelic CEBPA mutations, DNMT3A mutations, FLT3-ITD/NPM1 status, and ELN cytogenetic risk status were identified as independent prognostic factors for overall survival (OS) in the multivariable Cox regression analysis. A nomogram combining these predictors for individual risk estimation was established thereby.

Findings

The prognostic model demonstrated promising perfo

SUBMITTER: Ma TT 

PROVIDER: S-EPMC7689519 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature