Ontology highlight
ABSTRACT:
SUBMITTER: Mussell A
PROVIDER: S-EPMC7690829 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Mussell Ashley A Shen He H Chen Yanmin Y Mastri Michalis M Eng Kevin H KH Bshara Wiam W Frangou Costa C Zhang Jianmin J
Cancers 20201023 11
The Hippo signaling pathway is an evolutionarily conserved pathway that was initially discovered in <i>Drosophila melanogaster</i> and was later found to have mammalian orthologues. The key effector proteins in this pathway, YAP/TAZ, are often dysregulated in cancer, leading to a high degree of cell proliferation, migration, metastasis and cancer stem cell populations. Due to these malignant phenotypes it is important to understand the regulation of YAP/TAZ at the protein level. Using an siRNA l ...[more]