Dataset Information

Exploration in the Presence of Mother in Typically and Non-typically Developing Pre-walking Human Infants.

ABSTRACT: In previous phenotyping studies of mouse and rat exploratory behavior we developed a computational exploratory data analysis methodology including videotaping, tracking, preparatory methods for customized data analysis, a methodology for improving the replicability of results across laboratories, and algorithmic design for exposing the natural reference places (origins) used by animals during exploration. We then measured the animals' paths in reference to these origins, revealing robust, highly replicable modules termed excursions, which are performed from the origin into the environment and back to the origin. Origin-related exploration has been claimed to be phylogenetically conserved across the vertebrates. In the current study we use the same methodology to examine whether origin-related exploration has also been conserved in human pre-walking typically developing (TD) and a group of non-typically developing (NTD) infants in the presence of their stationary mother. The NTDs had been referred to a center for the early treatment of autism in infancy by pediatric neurologists and clinicians. The TDs established a reference place (origin) at mother's place and exhibited a modular partitioning of their path into excursions performed in reference to mother, visiting her often, and reaching closely. In contrast, the NTDs did not establish a distinct origin at the mother's place, or any other place, and did not partition the exploratory path into excursions. Once this difference is validated, the differences between the human infant groups may serve as an early referral tool for child development specialists. The absence of distinct modularity in human infants at risk of autism spectrum disorder can guide the search for animal models for this disorder in translational research.

SUBMITTER: Frostig T

PROVIDER: S-EPMC7691591 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Exploration in the Presence of Mother in Typically and Non-typically Developing Pre-walking Human Infants.

Frostig Tzviel T Alonim Hanna H Scheingesicht Giora G Benjamini Yoav Y Golani Ilan I

Frontiers in behavioral neuroscience 20201113

In previous phenotyping studies of mouse and rat exploratory behavior we developed a computational exploratory data analysis methodology including videotaping, tracking, preparatory methods for customized data analysis, a methodology for improving the replicability of results across laboratories, and algorithmic design for exposing the natural reference places (origins) used by animals during exploration. We then measured the animals' paths in reference to these origins, revealing robust, highly ...[more]

PMID: 33281573

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Project description:BackgroundMotion analysis is commonly used to evaluate joint kinetics in children with cerebral palsy who exhibit gait disorders. However, one cannot readily infer muscle-tendon forces from joint kinetics. This study investigates the use of shear wave tensiometry to characterize Achilles and patellar tendon forces during gait.Research questionHow do Achilles and patellar tendon wave speed and loading modulate with walking speed in typically developing children?MethodsTwelve typically developing children (9-16 years old) walked on an instrumented treadmill with shear wave tensiometers over their Achilles (n = 11) and patellar (n = 9) tendons. Wave speeds were recorded at five leg length-normalized walking speeds (very slow to very fast). Achilles and patellar tendon moment arms were measured with synchronized ultrasound and motion capture. The tendon wave speed-load relationship was calibrated at the typical walking speed and used to estimate tendon loading at other walking speeds.ResultsCharacteristic Achilles and patellar tendon wave speed trajectories exhibited two peaks over a gait cycle. Peak Achilles tendon force closely aligned with peak ankle plantarflexor moment during pushoff, though force exhibited less modulation with walking speed. A second peak in late swing Achilles loading, which was not evident from the ankle moment, increased significantly with walking speed (p < 0.001). The two peaks in patellar tendon loading occurred at 12 ± 1% and 68 ± 6% of the gait cycle, matching the timing of peak knee extension moment in early stance and early swing. Both patellar tendon load peaks increased significantly with walking speed (p < 0.05).SignificanceThis is the first study to use shear wave tensiometry to characterize Achilles and patellar tendon loading during gait in children. These data could serve as a normative comparison when using tensiometry to identify abnormal tendon loading patterns in individuals who exhibit equinus and/or crouch gait.

Dataset Information

Exploration in the Presence of Mother in Typically and Non-typically Developing Pre-walking Human Infants.

Publications

Exploration in the Presence of Mother in Typically and Non-typically Developing Pre-walking Human Infants.

Similar Datasets

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