Ontology highlight
ABSTRACT:
SUBMITTER: Dennis JE
PROVIDER: S-EPMC7691651 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Dennis James E JE Whitney George Adam GA Rai Jyoti J Fernandes Russell J RJ Kean Thomas J TJ
Frontiers in bioengineering and biotechnology 20201113
Cartilage tissue has been recalcitrant to tissue engineering approaches. In this study, human chondrocytes were formed into self-assembled cartilage sheets, cultured in physiologic (5%) and atmospheric (20%) oxygen conditions and underwent biochemical, histological and biomechanical analysis at 1- and 2-months. The results indicated that sheets formed at physiological oxygen tension were thicker, contained greater amounts of glycosaminoglycans (GAGs) and type II collagen, and had greater compres ...[more]