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Association of Adipose Tissue Distribution With Type 2 Diabetes in Breast Cancer Patients.

ABSTRACT: Purpose: We examined the association of adipose tissue distribution with type 2 diabetes (T2D) in breast cancer patients.

Methods: Participants (N?=?238) diagnosed with breast cancer at 20-75?years old who received breast cancer treatment at a major hospital from January 1, 2012, to December 31, 2017, with at least one completed and identifiable abdominal or pelvic computed tomography (CT) scan and data regarding race and ethnicity were included. Thirty-two breast cancer patients were identified as T2D patients after their breast cancer diagnoses. The adipose tissue distribution (visceral fat area [VFA], subcutaneous fat area [SFA], and the ratio of VFA to SFA [VFA/SFA]) was quantified on CT images of the third lumbar vertebra. T2D status was retrieved from patients' electronic medical records. The association of adipose tissue distribution with T2D in women with breast cancer was examined using multivariable logistic regression.

Results: Participants with T2D had significantly smaller SFA compared to those without T2D (odds ratio [OR]?=?0.88, 95% confidence interval [95% CI]?=?0.81-0.96, per 10?cm² SFA). A positive association of VFA/SFA ratio with T2D was observed (OR?=?19.57, 95% CI?=?3.26-117.42, per unit VFA/SFA), although the estimate was imprecise.

Conclusions: The amount of subcutaneous adipose tissue was inversely associated with T2D, and the ratio of the amount of visceral adipose tissue to the amount of subcutaneous adipose tissue was positively associated with T2D in breast cancer patients.

SUBMITTER: Qi J

PROVIDER: S-EPMC7691945 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Association of Adipose Tissue Distribution With Type 2 Diabetes in Breast Cancer Patients.

Qi Jia J Hu Hui H Yaghjyan Lusine L An Lejun L Kalim Harris A HA Cooke Erinn O EO Cheng Ting-Yuan David TD

Breast cancer : basic and clinical research 20201123

<h4>Purpose</h4>We examined the association of adipose tissue distribution with type 2 diabetes (T2D) in breast cancer patients.<h4>Methods</h4>Participants (N = 238) diagnosed with breast cancer at 20-75 years old who received breast cancer treatment at a major hospital from January 1, 2012, to December 31, 2017, with at least one completed and identifiable abdominal or pelvic computed tomography (CT) scan and data regarding race and ethnicity were included. Thirty-two breast cancer patients we ...[more]

PMID: 33281450

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Project description:BackgroundCord blood leptin and adiponectin are adipokines known to be associated with birth weight and overall infant adiposity. However, few studies have investigated their associations with abdominal adiposity in neonates. We examined maternal factors associated with cord blood leptin and adiponectin, and the association of these adipokines with neonatal adiposity and abdominal fat distribution measured by magnetic resonance imaging (MRI) in an Asian mother-offspring cohort.MethodsGrowing Up in Singapore Towards healthy Outcomes (GUSTO), is a prospective mother-offspring birth cohort study in Singapore. Cord blood plasma leptin and adiponectin concentrations were measured using Luminex and Enzyme-Linked Immunosorbent Assay respectively in 816 infants. A total of 271 neonates underwent MRI within the first 2-weeks after delivery. Abdominal superficial (sSAT), deep subcutaneous (dSAT), and intra-abdominal (IAT) adipose tissue compartment volumes were quantified from MRI images. Multivariable regression analyses were performed.ResultsIndian or Malay ethnicity, female sex, and gestational age were positively associated with cord blood leptin and adiponectin concentrations. Maternal gestational diabetes (GDM) positively associated with cord blood leptin concentrations but inversely associated with cord blood adiponectin concentrations. Maternal pre-pregnancy body mass index (BMI) showed a positive relationship with cord blood leptin but not with adiponectin concentrations. Each SD increase in cord blood leptin was associated with higher neonatal sSAT, dSAT and IAT; differences in SD (95% CI): 0.258 (0.142, 0.374), 0.386 (0.254, 0.517) and 0.250 (0.118, 0.383), respectively. Similarly, each SD increase in cord blood adiponectin was associated with higher neonatal sSAT and dSAT; differences in SD (95% CI): 0.185 (0.096, 0.274) and 0.173 (0.067, 0.278), respectively. The association between cord blood adiponectin and neonatal adiposity was observed in neonates of obese mothers only.ConclusionsCord blood leptin and adiponectin concentrations were associated with ethnicity, maternal BMI and GDM, sex and gestational age. Both adipokines showed positive association with neonatal abdominal adiposity.

Dataset Information

Association of Adipose Tissue Distribution With Type 2 Diabetes in Breast Cancer Patients.

Publications

Association of Adipose Tissue Distribution With Type 2 Diabetes in Breast Cancer Patients.

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