Ontology highlight
ABSTRACT:
SUBMITTER: Italiano A
PROVIDER: S-EPMC7692104 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Italiano Antoine A Nanda Shivani S Briggs Andrew A Garcia-Foncillas Jesus J Lassen Ulrik U Vassal Gilles G Kummar Shivaani S van Tilburg Cornelis M CM Hong David S DS Laetsch Theodore W TW Keating Karen K Reeves John A JA Fellous Marc M Childs Barrett H BH Drilon Alexander A Hyman David M DM
Cancers 20201104 11
Randomized controlled basket trials investigating drugs targeting a rare molecular alteration are challenging. Using patients as their own control overcomes some of these challenges. Growth modulation index (GMI) is the ratio of progression-free survival (PFS) on the current therapy to time to progression (TTP) on the last prior line of therapy; GMI ≥ 1.33 is considered a threshold of meaningful clinical activity. In a retrospective, exploratory analysis among patients with advanced tropomyosin ...[more]