Ontology highlight
ABSTRACT:
SUBMITTER: Hashimoto R
PROVIDER: S-EPMC7692916 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Hashimoto Ryu R Minoshima Masafumi M Kikuta Junichi J Yari Shinya S Bull Steven D SD Ishii Masaru M Kikuchi Kazuya K
Angewandte Chemie (International ed. in English) 20200908 47
A rationally designed pH-activatable fluorescent probe (pHocas-RIS) has been used to measure localised pH levels in osteocytic lacunae in bone tissue. Conjugation of the moderate bone-binding drug risedronate to a pH-activatable BODIPY fluorophore enables the probe to penetrate osteocytic lacunae cavities that are embedded deep within the bone matrix. After injection of pHocas-RIS, any osteocytic lacunae caused by bone-resorbing osteocytes cause the probe to fluoresce in vivo, thus allowing imag ...[more]