Ontology highlight
ABSTRACT:
SUBMITTER: Chen YC
PROVIDER: S-EPMC7695343 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Chen Yi-Chun YC Chang Yao-Tsung YT Chen Chiu-Yueh CY Shiu Jia-Hau JH Cheng Chun-Ho CH Huang Chun-Hao CH Chen Ju-Fei JF Chuang Woei-Jer WJ
Toxins 20201109 11
Echistatin (Ech) is a short disintegrin with a long <sup>42</sup>NPHKGPAT C-terminal tail. We determined the 3-D structure of Ech by X-ray crystallography. Superimposition of the structures of chains A and B showed conformational differences in their RGD loops and C-termini. The chain A structure is consistent with our NMR analysis that the GPAT residues of the C-terminus cannot be observed due to high flexibility. The hydrogen bond patterns of the RGD loop and between the RGD loop and C-terminu ...[more]