Dataset Information

Different polymorphisms in HIF-1? may exhibit different effects on cancer risk in Asians: evidence from nearly forty thousand participants.

ABSTRACT: The effect of different SNPs in HIF-1? and cancer susceptibility remain indistinct. Here, we evaluated the association between all identified SNPs (rs11549465, rs11549467 and rs2057482) in HIF-1? and the overall risk of cancer in all case-control studies published before April 2020. A total of 54 articles including 56 case-control studies were included in this analysis. We found that variant genotypes of rs11549465 and rs11549467 were associated with a significantly increased overall cancer risk. In contrast, the variant T allele of rs2057482 showed a significantly reduced risk of overall cancer. In addition, variant genotypes of the three studied SNPs exhibited a significant association with cancer risk in Asians and specific cancer types. Meanwhile, HIF-1? was significantly highly expressed in head and neck squamous cell carcinoma and pancreatic cancer tissues. More importantly, survival analysis indicated that the high expression of HIF-1? was associated with a poor survival in patients with lung cancer. These findings further provided evidence that different SNPs in HIF-1? may exhibit different effects on overall cancer risk; these effects were ethnicity and type-specific. Further studies with functional evaluations are required to confirm the biological mechanisms underlying the role of HIF-1? SNPs in cancer development and progression.

SUBMITTER: Liu Y

PROVIDER: S-EPMC7695358 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Different polymorphisms in HIF-1α may exhibit different effects on cancer risk in Asians: evidence from nearly forty thousand participants.

Liu Yichen Y Zhu Xiaoqi X Zhou Xiaoyi X Cheng Jingwen J Fu Xiaoyu X Xu Jingsheng J Wang Yuya Y Zhong Yueping Y Chu Minjie M

Aging 20201104 21

The effect of different SNPs in <i>HIF-1α</i> and cancer susceptibility remain indistinct. Here, we evaluated the association between all identified SNPs (rs11549465, rs11549467 and rs2057482) in <i>HIF-1α</i> and the overall risk of cancer in all case-control studies published before April 2020. A total of 54 articles including 56 case-control studies were included in this analysis. We found that variant genotypes of rs11549465 and rs11549467 were associated with a significantly increased overa ...[more]

PMID: 33154192

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Dataset Information

Different polymorphisms in HIF-1? may exhibit different effects on cancer risk in Asians: evidence from nearly forty thousand participants.

Publications

Different polymorphisms in HIF-1α may exhibit different effects on cancer risk in Asians: evidence from nearly forty thousand participants.

Similar Datasets

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