Ontology highlight
ABSTRACT:
SUBMITTER: Miyazaki K
PROVIDER: S-EPMC7695476 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Miyazaki Katsuhiko K Miyazaki Kayoko W KW Sivori Gaston G Yamanaka Akihiro A Tanaka Kenji F KF Doya Kenji K
Science advances 20201127 48
Optogenetic activation of serotonergic neurons in the dorsal raphe nucleus (DRN) enhances patience when waiting for future rewards, and this effect is maximized by both high probability and high timing uncertainty of reward. Here, we explored which serotonin projection areas contribute to these effects using optogenetic axon terminal stimulation. We found that serotonin stimulation in the orbitofrontal cortex (OFC) is nearly as effective as that in the DRN for promoting waiting, while in the nuc ...[more]