Ontology highlight
ABSTRACT:
SUBMITTER: Song H
PROVIDER: S-EPMC7695691 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Song Hui H Zhao Chunyuan C Yu Zhongxia Z Li Qizhao Q Yan Rongzhen R Qin Ying Y Jia Mutian M Zhao Wei W
Nature communications 20201127 1
NOD-like receptor protein 3 (NLRP3) detects microbial infections or endogenous danger signals and activates the NLRP3 inflammasome, which has important functions in host defense and contributes to the pathogenesis of inflammatory diseases, and thereby needs to be tightly controlled. Deubiquitination of NLRP3 is considered a key step in NLRP3 inflammasome activation. However, the mechanisms by which deubiquitination controls NLRP3 inflammasome activation are unclear. Here, we show that the UAF1/U ...[more]