Long-Term Risk of Comorbidity after IgA Vasculitis in Childhood: A Population-Based Cohort Study.
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ABSTRACT: Introduction
Patients with IgA vasculitis (IgAV) may require aggressive treatment and are prone to disease relapses, and IgA deposition in tissues can persist. We investigated whether these factors predispose to long-term morbidity in children with IgAV.Methods
Observational cohort study comparing rates for comorbidity development by Charlson comorbidity index (CCI) and rates for hospitalization, procedures, and emergency department (ED) visits over a 20-year period for IgAV patients?ResultsPatient survival (99.1 vs. 99.7%, p?=?0.6) and overall comorbidity accrual CCI (0.21 vs. 0.23, p?=?0.7) were similar for IgAV patients and hospital-based controls after 20 years. IgAV patients did not develop other rheumatic diseases, but more often were diagnosed with peptic ulcer and end-stage renal failure. Hospitalization rates were three times higher for IgAV patients (RR 3.41 CI 3.04-3.82) in the first year following diagnosis, while ED attendance rates were higher in subsequent years (RR 1.29; 1.02-1.04; p?ConclusionsChildhood IgAV patients have good long-term prognosis despite the occurrence of end-stage renal failure and compared to hospital-based controls are at not at increased risk for other comorbidity or rheumatic disease.
SUBMITTER: Nossent J
PROVIDER: S-EPMC7695788 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Long-Term Risk of Comorbidity after IgA Vasculitis in Childhood: A Population-Based Cohort Study.
Nossent Johannes J Raymond Warren W Keen Helen H Inderjeeth Charles C Preen David D
Rheumatology and therapy 20201015 4
<h4>Introduction</h4>Patients with IgA vasculitis (IgAV) may require aggressive treatment and are prone to disease relapses, and IgA deposition in tissues can persist. We investigated whether these factors predispose to long-term morbidity in children with IgAV.<h4>Methods</h4>Observational cohort study comparing rates for comorbidity development by Charlson comorbidity index (CCI) and rates for hospitalization, procedures, and emergency department (ED) visits over a 20-year period for IgAV pati ...[more]
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