Ontology highlight
ABSTRACT:
SUBMITTER: Parayath NN
PROVIDER: S-EPMC7695830 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Parayath N N NN Stephan S B SB Koehne A L AL Nelson P S PS Stephan M T MT
Nature communications 20201127 1
Engineering chimeric antigen receptors (CAR) or T cell receptors (TCR) helps create disease-specific T cells for targeted therapy, but the cost and rigor associated with manufacturing engineered T cells ex vivo can be prohibitive, so programing T cells in vivo may be a viable alternative. Here we report an injectable nanocarrier that delivers in vitro-transcribed (IVT) CAR or TCR mRNA for transiently reprograming of circulating T cells to recognize disease-relevant antigens. In mouse models of h ...[more]