Ontology highlight
ABSTRACT:
SUBMITTER: Karuna M P
PROVIDER: S-EPMC7696345 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Karuna M Pradhipa P Witte Leonie L Linnemannstoens Karen K Choezom Dolma D Danieli-Mackay Adi A Honemann-Capito Mona M Gross Julia Christina JC
Biomolecules 20201116 11
Sensitive factor attachment protein receptors (SNARE) proteins are important mediators of protein trafficking that regulate the membrane fusion of specific vesicle populations and their target organelles. The SNARE protein Ykt6 lacks a transmembrane domain and attaches to different organelle membranes. Mechanistically, Ykt6 activity is thought to be regulated by a conformational change from a closed cytosolic form to an open membrane-bound form, yet the mechanism that regulates this transition i ...[more]