Ontology highlight
ABSTRACT:
SUBMITTER: Pelaez Coyotl EA
PROVIDER: S-EPMC7697726 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Peláez Coyotl Erika A EA Barrios Palacios Jacqueline J Muciño Gabriel G Moreno-Blas Daniel D Costas Miguel M Montiel Montes Teresa T Diener Christian C Uribe-Carvajal Salvador S Massieu Lourdes L Castro-Obregón Susana S Espinosa Octavio Ramos OR Mata Espinosa Dulce D Barrios-Payan Jorge J León Contreras Juan Carlos JC Corzo Gerardo G Hernández-Pando Rogelio R Del Rio Gabriel G
Pharmaceutics 20201109 11
<i>Mycobacterium tuberculosis</i> (MTB) is the principal cause of human tuberculosis (TB), which is a serious health problem worldwide. The development of innovative therapeutic modalities to treat TB is mainly due to the emergence of multi drug resistant (MDR) TB. Autophagy is a cell-host defense process. Previous studies have reported that autophagy-activating agents eliminate intracellular MDR MTB. Thus, combining a direct antibiotic activity against circulating bacteria with autophagy activa ...[more]