ROS-Induced SIRT2 Upregulation Contributes to Cisplatin Sensitivity in Ovarian Cancer.
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ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC7698236 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
ROS-Induced SIRT2 Upregulation Contributes to Cisplatin Sensitivity in Ovarian Cancer.
Wang Wenyu W Im Jihye J Kim Soochi S Jang Suin S Han Youngjin Y Yang Kyung-Min KM Kim Seong-Jin SJ Dhanasekaran Danny N DN Song Yong Sang YS
Antioxidants (Basel, Switzerland) 20201116 11
Cisplatin resistance remains a significant obstacle for improving the clinical outcome of ovarian cancer patients. Recent studies have demonstrated that cisplatin is an important inducer of intracellullar reactive oxygen species (ROS), triggering cancer cell death. Sirtuin 2 (SIRT2), a member of class III NAD<sup>+</sup> dependent histone deacetylases (HDACs), has been reported to be involved in regulating cancer hallmarks including drug response. In this study, we aimed to identify the role of ...[more]
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