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Absence of mgrB Alleviates Negative Growth Effects of Colistin Resistance in Enterobacter cloacae.

ABSTRACT: Colistin is an important last-line antibiotic to treat highly resistant Enterobacter infections. Resistance to colistin has emerged among clinical isolates but has been associated with a significant growth defect. Here, we describe a clinical Enterobacter isolate with a deletion of mgrB, a regulator of colistin resistance, leading to high-level resistance in the absence of a growth defect. The identification of a path to resistance unrestrained by growth defects suggests colistin resistance could become more common in Enterobacter.

SUBMITTER: Wozniak JE

PROVIDER: S-EPMC7699182 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Absence of mgrB Alleviates Negative Growth Effects of Colistin Resistance in Enterobacter cloacae.

Wozniak Jessie E JE Chande Aroon T AT Burd Eileen M EM Band Victor I VI Satola Sarah W SW Farley Monica M MM Jacob Jesse T JT Jordan I King IK Weiss David S DS

Antibiotics (Basel, Switzerland) 20201119 11

Colistin is an important last-line antibiotic to treat highly resistant Enterobacter infections. Resistance to colistin has emerged among clinical isolates but has been associated with a significant growth defect. Here, we describe a clinical Enterobacter isolate with a deletion of mgrB, a regulator of colistin resistance, leading to high-level resistance in the absence of a growth defect. The identification of a path to resistance unrestrained by growth defects suggests col ...[more]

PMID: 33227907

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