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Absence of mgrB Alleviates Negative Growth Effects of Colistin Resistance in Enterobacter cloacae.


ABSTRACT: Colistin is an important last-line antibiotic to treat highly resistant Enterobacter infections. Resistance to colistin has emerged among clinical isolates but has been associated with a significant growth defect. Here, we describe a clinical Enterobacter isolate with a deletion of mgrB, a regulator of colistin resistance, leading to high-level resistance in the absence of a growth defect. The identification of a path to resistance unrestrained by growth defects suggests colistin resistance could become more common in Enterobacter.

SUBMITTER: Wozniak JE 

PROVIDER: S-EPMC7699182 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Absence of <i>mgrB</i> Alleviates Negative Growth Effects of Colistin Resistance in <i>Enterobacter cloacae</i>.

Wozniak Jessie E JE   Chande Aroon T AT   Burd Eileen M EM   Band Victor I VI   Satola Sarah W SW   Farley Monica M MM   Jacob Jesse T JT   Jordan I King IK   Weiss David S DS  

Antibiotics (Basel, Switzerland) 20201119 11


Colistin is an important last-line antibiotic to treat highly resistant <i>Enterobacter</i> infections. Resistance to colistin has emerged among clinical isolates but has been associated with a significant growth defect. Here, we describe a clinical <i>Enterobacter</i> isolate with a deletion of <i>mgrB</i>, a regulator of colistin resistance, leading to high-level resistance in the absence of a growth defect. The identification of a path to resistance unrestrained by growth defects suggests col  ...[more]

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