Unknown

Dataset Information

0

11C-Choline PET/CT vs. 99mTc-MIBI/123Iodide Subtraction SPECT/CT for Preoperative Detection of Abnormal Parathyroid Glands in Primary Hyperparathyroidism: A Prospective, Single-Centre Clinical Trial in 60 Patients.


ABSTRACT: In patients with primary hyperparathyroidism (PHPT) locating hyperfunctioning glands (HPGs) is crucial when planning minimally invasive surgery. Dual-isotope subtraction scintigraphy with 99mTc-MIBI/123Iodide using SPECT/CT and planar pinhole imaging (Method A) has previously shown a sensitivity >93%. However, the method is costly and time consuming and entails a high radiation dose. 11C-Choline PET/CT (Method B) is an appealing candidate method unencumbered by these disadvantages. Sixty patients with newly diagnosed PHPT participated and were scanned using both methods prior to parathyroidectomy. We investigated whether sensitivities of Method A and Method B are similar in a method-to-method comparison when using surgical findings as the true location. At the patient level, sensitivities were (A) 0.98 (95% CI: 0.90-1.00) and (B) 1.00 (95% CI: 0.93-1.00). At the gland level, sensitivities were (A) 0.88 (95% CI: 0.78-0.94) and (B) 0.87 (95% CI: 0.76-0.92). With a non-inferiority margin of ∆ = -0.1, we found a 1-sided p-value < 0.001. Our methods comparison study found that sensitivity of Method B was not inferior to Method A. We suggest that 11C-Choline PET/CT is a clinically relevant first-choice candidate for preoperative imaging of PHPT and that Method B can likely replace Method A in the near future.

SUBMITTER: Ismail A 

PROVIDER: S-EPMC7699496 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

<sup>11</sup>C-Choline PET/CT vs. <sup>99m</sup>Tc-MIBI/<sup>123</sup>Iodide Subtraction SPECT/CT for Preoperative Detection of Abnormal Parathyroid Glands in Primary Hyperparathyroidism: A Prospective, Single-Centre Clinical Trial in 60 Patients.

Ismail Afefah A   Christensen Julie Wulf JW   Krakauer Martin M   Søndergaard Susanne Bonnichsen SB   Zerahn Bo B   Nygaard Birte B   Bennedbæk Finn Noe FN   Kristensen Bent B   Jensen Lars Thorbjørn LT  

Diagnostics (Basel, Switzerland) 20201119 11


<h4>Background</h4>In patients with primary hyperparathyroidism (PHPT) locating hyperfunctioning glands (HPGs) is crucial when planning minimally invasive surgery. Dual-isotope subtraction scintigraphy with <sup>99m</sup>Tc-MIBI/<sup>123</sup>Iodide using SPECT/CT and planar pinhole imaging (Method A) has previously shown a sensitivity >93%. However, the method is costly and time consuming and entails a high radiation dose. <sup>11</sup>C-Choline PET/CT (Method B) is an appealing candidate metho  ...[more]

Similar Datasets

| S-EPMC5829113 | biostudies-literature
| S-EPMC7555464 | biostudies-literature
| S-EPMC4358706 | biostudies-literature
| S-EPMC7440755 | biostudies-literature
| S-EPMC10722006 | biostudies-literature
| S-EPMC6933043 | biostudies-literature
| S-EPMC7791717 | biostudies-literature
| S-EPMC8257818 | biostudies-literature
| S-EPMC3716783 | biostudies-other
| S-EPMC7039984 | biostudies-literature