Dataset Information

Rosette Trajectories Enable Ungated, Motion-Robust, Simultaneous Cardiac and Liver T₂ * Iron Assessment.

ABSTRACT:

Background

Quantitative T₂ * MRI is the standard of care for the assessment of iron overload. However, patient motion corrupts T₂ * estimates.

Purpose

To develop and evaluate a motion-robust, simultaneous cardiac and liver T₂ * imaging approach using non-Cartesian, rosette sampling and a model-based reconstruction as compared to clinical-standard Cartesian MRI.

Study type

Prospective.

Phantom/population

Six ferumoxytol-containing phantoms (26-288 μg/mL). Eight healthy subjects and 18 patients referred for clinically indicated iron overload assessment.

Field strength/sequence

1.5T, 2D Cartesian and rosette gradient echo (GRE) ASSESSMENT: GRE T₂ * values were validated in ferumoxytol phantoms. In healthy subjects, test-retest and spatial coefficient of variation (CoV) analysis was performed during three breathing conditions. Cartesian and rosette T₂ * were compared using correlation and Bland-Altman analysis. Images were rated by three experienced radiologists on a 5-point scale.

Statistical tests

Linear regression, analysis of variance (ANOVA), and paired Student's t-testing were used to compare reproducibility and variability metrics in Cartesian and rosette scans. The Wilcoxon rank test was used to assess reader score comparisons and reader reliability was measured using intraclass correlation analysis.

Results

Rosette R2* (1/T₂ *) was linearly correlated with ferumoxytol concentration (r² = 1.00) and not significantly different than Cartesian values (P = 0.16). During breath-holding, ungated rosette liver and heart T₂ * had lower spatial CoV (liver: 18.4 ± 9.3% Cartesian, 8.8% ± 3.4% rosette, P = 0.02, heart: 37.7% ± 14.3% Cartesian, 13.4% ± 1.7% rosette, P = 0.001) and higher-quality scores (liver: 3.3 [3.0-3.6] Cartesian, 4.7 [4.1-4.9] rosette, P = 0.005, heart: 3.0 [2.3-3] Cartesian, 4.5 [3.8-5.0] rosette, P = 0.005) compared to Cartesian values. During free-breathing and failed breath-holding, Cartesian images had very poor to average image quality with significant artifacts, whereas rosette remained very good, with minimal artifacts (P = 0.001).

Data conclusion

Rosette k-sampling with a model-based reconstruction offers a clinically useful motion-robust T₂ * mapping approach for iron quantification. J. MAGN. RESON. IMAGING 2020;52:1688-1698.

SUBMITTER: Bush AM

PROVIDER: S-EPMC7699670 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Dataset Information

Rosette Trajectories Enable Ungated, Motion-Robust, Simultaneous Cardiac and Liver T₂ * Iron Assessment.

Background

Purpose

Study type

Phantom/population

Field strength/sequence

Statistical tests

Results

Data conclusion

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Background

Purpose

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Statistical tests

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