Ontology highlight
ABSTRACT:
SUBMITTER: Aladdin A
PROVIDER: S-EPMC7699873 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Aladdin Azzam A Yao Yanhua Y Yang Ciyu C Kahlert Günther G Ghani Marvi M Király Nikolett N Boratkó Anita A Uray Karen K Dittmar Gunnar G Tar Krisztina K
Biomolecules 20201120 11
The Blm10/PA200 family of proteasome activators modulates the peptidase activity of the core particle (20S CP). They participate in opening the 20S CP gate, thus facilitating the degradation of unstructured proteins such as tau and Dnm1 in a ubiquitin- and ATP-independent manner. Furthermore, PA200 also participates in the degradation of acetylated histones. In our study, we use a combination of yeast and human cell systems to investigate the role of Blm10/PA200 in the degradation of N-terminal ...[more]