Ontology highlight
ABSTRACT:
SUBMITTER: Oksuz O
PROVIDER: S-EPMC7700016 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Molecular cell 20180601 6
Polycomb repressive complex 2 (PRC2) maintains gene silencing by catalyzing methylation of histone H3 at lysine 27 (H3K27me2/3) within chromatin. By designing a system whereby PRC2-mediated repressive domains were collapsed and then reconstructed in an inducible fashion in vivo, a two-step mechanism of H3K27me2/3 domain formation became evident. First, PRC2 is stably recruited by the actions of JARID2 and MTF2 to a limited number of spatially interacting "nucleation sites," creating H3K27me3-for ...[more]