Ontology highlight
ABSTRACT:
SUBMITTER: Araldi RP
PROVIDER: S-EPMC7700534 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Araldi Rodrigo Pinheiro RP de Melo Thatiana Correa TC Levy Débora D de Souza Dener Madeiro DM Maurício Beatriz B Colozza-Gama Gabriel Avelar GA Bydlowski Sergio Paulo SP Peng Hongzhuang H Rauscher Frank J FJ Cerutti Janete Maria JM
Cells 20201123 11
Although papillary thyroid carcinoma (PTC) has a good prognosis, 20-90% of patients show metastasis to regional lymph nodes and 10-15% of patients show metastasis to distant sites. Metastatic disease represents the main clinical challenge that impacts survival rate. We previously showed that LIMD2 was a novel metastasis-associated gene. In this study, to interrogate the role of LIMD2 in cancer invasion and metastasis, we used CRISPR-mediated knockout (KO) of LIMD2 in PTC cells (BCPAP and TPC1). ...[more]