Ontology highlight
ABSTRACT:
SUBMITTER: Chang SC
PROVIDER: S-EPMC7700556 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Chang Shih-Ching SC Li Anna Fen-Yau AF Lin Pei-Ching PC Lin Chun-Chi CC Lin Hung-Hsin HH Huang Shen-Chieh SC Lin Chien-Hsing CH Liang Wen-Yi WY Chen Wei-Shone WS Jiang Jeng-Kai JK Lin Jen-Kou JK Yang Shung-Haur SH Lan Yuan-Tzu YT
Cancers 20201123 11
<h4>Background</h4>The 5'-C-phosphate-G-3' island methylator phenotype (CIMP) is a specific phenotype of colorectal cancer (CRC) associated with microsatellite instability-high (MSI-high) tumors.<h4>Methods</h4>In this study, we determined the CIMP status using eight methylation markers in 92 MSI-high CRC patients after excluding five germline mismatch repair (MMR) gene mutations analyzed by next-generation sequencing (NGS) and confirmed by Sanger sequencing. The mutation spectra of 22 common CR ...[more]